Incurin (estriol) Tablets

What are Incurin (estriol) Tablets?

INCURIN (estriol) Tablets are an effective treatment for the control of estrogen-responsive urinary incontinence in spayed female dogs that contains estriol, a naturally occurring, short-acting estrogen found in female dogs, with the convenience of once-a-day dosing.

Suitable for:

Spayed Female Dogs with Urinary Inconteninence

Benefits:

• Proven effective in reducing or eliminating urinary incontinence in spayed female dogs
• 93% of dogs treated were improved or continent by 6 weeks
• Convenient, once-a-day dosing
• One simple starting dose for all female dogs and just 1 tablet size
• Helps bring confidence to treating incontinence - INCURIN has been safely and effectively used worldwide for more than 20 years, and pet parents agree that it works.

How it works:

Incurin (estriol) Tablets are indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs. Incurin (estriol) Tablets contain the active ingredient estriol, a natural estrogen, which increases the resting muscle tone of the urethra in female dogs and can be used in the treatment of urinary incontinence due to estrogen depletion. It is given once a day with a starting dose of two tablets for any female dog, regardless of age or weight. The dose of Incurin (estriol) Tablets is then titrated down over time to the lowest effective dose.

What is the most important thing I should know about Incurin (estriol) Tablets?

Evaluation of factors contributing to urinary incontinence should be considered prior to administration of INCURIN® Tablets. Do not use with other estrogens. The concomitant use of INCURIN® Tablets with other estrogens or with glucocorticoids has not been evaluated. The safe use of INCURIN® Tablets has not been evaluated in intact female dogs, pregnant or lactating dogs, male dogs, dogs less than 1 year of age, or dogs with liver disease.

Cautions:

Human Warnings: Not for human use. Keep out of the reach of children. Women who are of child-bearing age or those who are breastfeeding should use caution when administering INCURIN® Tablets. Wash your hands with soap and water after administration to avoid exposure to the drug. Consult a physician in case of accidental ingestion by humans.
Animal Warnings: Some estrogens have been associated with bone marrow changes and an increased risk of mammary tumors. However, target animal safety study results and foreign post-market pharmacovigilance data for INCURIN® Tablets have shown that estriol-treated dogs are at low risk for developing these conditions.

Brand Name

Incurin (estriol) Tablets

Generic Name

Estriol

Manufacturer:

Merck

What is this medication used for:

Incurin (estriol) Tablets are used for the treatment and control of urinary incontinence that is estrogen-responsive for female dogs that have undergone ovariohysterectomy (surgical removal of the ovaries & uterus).

Availability:

Incurin (estriol) Tablets are available in a single foil-sealed blister pack of 30 estriol tablets (1 mg/tablet) and requires a prescription from your veterinarian.

How this medicine should be used:

The dose of INCURIN® Tablets is not dependent upon body weight. All dogs should receive an initial dose of 2 mg INCURIN® Tablets (2 tablets) orally once per day for a minimum of 14 days. After urinary incontinence is controlled, the lowest effective daily dose of INCURIN® Tablets should be determined by decreasing the dose in a step-wise manner from 2 mg once daily (2 tablets) to 1 mg once daily (1 tablet), then 0.5 mg once daily (1/2 tablet) depending upon the response of the individual dog. There should be a minimum of 7 days between each dose adjustment. After the lowest daily dose that controls urinary incontinence is identified, the dose may be decreased further by administering once every two days. Dogs should not receive more than 2 mg INCURIN® Tablets per day (2 tablets). If the dog does not respond to 2 mg of INCURIN® Tablets per day, the diagnosis should be re-assessed.

What are the side effects:

Reported adverse reactions include anorexia, emesis, polydipsia, and swollen vulva.

What special precautions are there:

The safety and effectiveness of Incurin (estriol) Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Incurin (estriol) Tablets are contraindicated in dogs showing polyuria (production of excessive amounts of urine) secondary to polydipsia (excessive thirst), or in pregnant dogs.

In the event of an overdose:

Contact your veterinarian immediately.

How should I store this medication:

Store at or below 77 °F (25°C) with excursions permitted up to 104°F (40°C).