What is Credelio Quattro 6-in-1 Parasite Protection Chewable Tablet for Dogs?

Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) is the broadest* parasite protection of its kind covering 6 types of parasites in one chewable tablet.

It protects against ticks, fleas, heartworm disease and the three intestinal worms that can be passed to humans — tapeworms, roundworms and hookworms^†. Credelio Quattro is effective and works fast where it counts.

It kills >99% of fleas within 8 hours of administration and remains effective for an entire month. What's more, Credelio Quattro contains lotilaner that kills ticks** twice as fast^†† as sarolaner in Simparica Trio and afoxolaner in NexGard^†††.

_{*Based on label comparison of the number of parasite types covered in a chewable that covers ticks. **Amblyomma americanum (lone star tick)
†Uncinaria stenocephala ††Based on the time to statistical significance vs. control in a study on Day 21 and Day 28 for reinfestations. The study compared Credelio (lotilaner)—not Credelio Quattro, which contains lotilaner as well as moxidectin, praziquantel, and pyrantel—to the active ingredients in Simparica Trio (sarolaner, moxidectin, and pyrantel) and NexGard (afoxolaner). †††Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG, Bell MC, Beltz MS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR, Sutherland CJ. Comparative speed of kill provided by lotilaner (Credelio), sarolaner (Simparica Trio), and afoxolaner (NexGard) to control Amblyomma americanum infestations on dogs. Parasit Vectors. 2024 Jul 20;17(1):313.}

Suitable for:

Dogs and Puppies (from 8 weeks of age & older, weighing 3.3 lbs or greater)

Indications:

Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm* and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater. Credelio Quattro is indicated for the prevention of heartworm disease and the treatment and control of roundworm, hookworm* and tapeworm infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations and the treatment and control of tick infestations for 1 month in dogs and puppies 8 weeks of age and older and weighing 3.3 pounds or greater.
_{*Uncinaria stenocephala}

Benefits:

• Credelio Quattro: The broadest* parasite protection - the first and only of its kind that protects dogs against 6 different types of parasites, including tapeworms, in one chewable tablet (*Based on label comparison of the number of parasite types covered in a chewable that covers ticks.)
• Brings Peace of Mind: This monthly flea and tick treatment also protects against heartworm disease and three intestinal worms that can be passed to humans – roundworms, hookworms† and tapeworms (†Uncinaria stenocephalam)
• Easy-to-Give Chewable: This FDA-approved parasite protection comes in a flavored chewable tablet that is given once a month with food
• Effective: In laboratory studies, Credelio Quattro was 100% effective against heartworm disease from the first monthly dose.
• Satisfaction Guaranteed: Backed by Elanco’s Canine Parasiticides Satisfaction Guarantee.

How does Credelio Quattro 6-in-1 Parasite Protection Chewable Tablet for Dogs work?

This FDA-approved medication delivers all the protection your dog needs in a convenient monthly chewable. It uses four powerful ingredients to provide the broadest* protection that lasts all month long by covering 6 types of parasites. Credelio Quattro comes in a tasty, easy-to-give chewable that's also meat allergy friendly***.  In fact, Credelio Quattro was accepted by nearly 9 out of 10 dogs.
_{*Based on label comparison of the number of parasite types covered in a chewable that covers ticks
***Elanco Animal Health. Data on file.}

Important Safety Information: 

Lotilaner, an ingredient in Credelio Quattro, belongs to the isoxazoline class and has been associated with neurologic adverse reactions like tremors, ataxia, and seizures even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infections before Credelio Quattro administration as it is not effective against adult D. immitis. The safe use in breeding, pregnant, or lactating dogs has not been evaluated. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. For complete safety information, please see Credelio Quattro product label or ask your veterinarian.
_{*Uncinaria stenocephala}

What is the most important information I should know about Credelio Quattro 6-in-1 Parasite Protection Chewable Tablet for Dogs ?

Credelio Quattro is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina), hookworm (adult Uncinaria stenocephala), and tapeworm (Dipylidium caninum , Taenia pisiformis , and Echinococcus granulosus) infections. Credelio Quattro kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), and Rhipicephalus sanguineus (brown dog tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 3.3 pounds or greater.

How should Credelio Quattro 6-in-1 Parasite Protection Chewable Tablet for Dogs be given/administered?

Credelio Quattro is given orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Credelio Quattro must be administered with food (see Clinical Pharmacology). Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If vomiting occurs within an hour after administration, readminister a new dose of Credelio Quattro. If a dose is missed, give Credelio Quattro immediately and resume a monthly dosing schedule.

Cautions:

Use Credelio Quattro with caution in dogs with a history of seizures or neurological disorders and avoid use in puppies under 8 weeks old or weighing less than 4.4 lbs. Consult your veterinarian before use in pregnant, nursing, or medically compromised dogs. Side effects may include vomiting, diarrhea, lethargy, or loss of appetite; contact your veterinarian if these persist. Administer only as directed, as overdose can be harmful. Keep out of reach of children and other pets, and wash hands after handling. If accidental ingestion occurs, seek immediate medical attention

How should I store this product?

Store at room temperature, away from sunlight, moisture, and extreme temperatures.