SAVE 50% ON NEXGARD W/AUTOSHIPUse code NEXGARD50 (Up to $50 max. Exclusions apply)
SAVE AN EXTRA $5 - $20 OFFUse code PETS in cart (Exclusions apply)
Prevents Heartworm Disease |
![]() |
![]() |
![]() |
Roundworms |
![]() |
![]() |
![]() |
Hookworms |
![]() |
![]() |
![]() |
Whipworms |
![]() |
![]() |
![]() |
Tapeworms |
![]() |
![]() |
![]() |
Fleas | Yes, Adult and Flea Eggs | Flea Eggs and Larvae |
![]() |
Other Parasites | Ear mites, Roundworms, and Hookworms in cats; Ear mites,Sarcoptic Mange and American dog ticks in dogs |
![]() |
Protects against 5 types of ticks |
Safe for Breeding, Pregnant or Nursing Pets |
![]() |
Has tested safely at normal doses. | The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs. |
Age/Weight Requirements | 6 weeks of age or older in puppies, 8 weeks of age or older in kittens, and no weight requirement | 4 weeks of age or older and weighing over 2 lbs | 8 weeks of age or older, weighing 2.8 lbs or more |
Rx Prescription Required |
![]() |
![]() |
![]() |
Dosage | Monthly | ||
Usage |
![]() |
![]() |
![]() |
Video | Coming soon | Coming soon | Coming soon |
Veterinarian Review (Michael Dym, VMD) | This versatile topical product has the widest range of protection of both internal and external parasites. In both cats and dogs, all 3 stages of the flea life cycle are effectively controlled,in addition to ear mites. For dogs, there is also the wonderful treatment benefit of killing hidden scabies mites on the skin, which are so difficult for veterinarians to find on routine skin scrapings at our offices. In fact, when either I or veterinary dermatologists are presented with a very itchy dog, in addition to our allergy workups, we will often treat with this topical every few weeks to treat and rule out any hidden scabies mites contributing to the pet's itching. . It is amazing how many dogs will respond to this treatment, leading me to believe that scabies mites are involved with alot more itching problems in dogs than I first learned about in vet school.. With the increased recognition and understanding of feline heartworm disease, this is often the first heartworm preventative that I will reach for in cats, especially given all of the other beneifts above. While it is often effective for canine heartworm prevention as well, I have heard of rare lapses in protection, so I usually combine this topical in dogs with one of the oral heartworm prevention medications like heartguard or interceptor. The only disadvantage I have seen is the rare reaction on cats of mild digestive upset and temporary hair loss at the site of application. It also has the wonderful benefits of being water proof in only 2 hours after application, and in being approved for use in puppies as young as 6 weeks of age. | Sentinel is a wonderful combination of the heartworm prevention pill interceptor and the flea control product program both in this one pill. Many clients enjoy the convenience of having such broad acting internal and external parasites in one pill, without having to worry about giving two separate medicines. Lufenuron, which is the main flea control ingredient, stops the flea life cycle in its track at the egg and larval stage, thus being like a birth control pill for fleas who get on our pets. Given that the main problem of fleas is how rapidly they reproduce, this pill literally stops escalating growth of flea populations, before they can become established in our homes, where most of the flea life cycle occurs. The main disadvantage to this product is that it does not kill or repell adult fleas, so in situations with already established heavy infestations, it is best combined with a great topical product like advantage or front line or with the oral adulticide flea pill capstar for maximal effect. The only other rare disadvantage I see is the slight increase in reactions when two products are combined into one like this, but fortunately this is not common in clinical practice. With milbemycin for prevention of heartworms and controlling and treating most common intestinal worms, I overall highly recommend this versatile product. | Coming soon |