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Kills Fleas |
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Repels Fleas |
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Kills Flea eggs and Larvae |
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Prevents all flea stages (eggs, pupae, larvae, and adult fleas) from developing. |
Kills Ticks |
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Repels Ticks |
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Kills and/or Repels Mosquitoes |
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Prevents Heartworm |
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Other Parasites Information | Treats, Prevents, and Controls Lice Infestations | Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation | Also kills biting and sand flies, live and mites for one month |
Waterproof (shampooing once a week can reduce effectiveness) |
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Safe for pregnant or nursing Pets | Consult your veterinarian |
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How long does it take to work | Kills fleas in 12 hours | Kills Fleas within 12 hours and Ticks within 48 hours | Starts to reduce flea feeding in just 5 minutes |
Taste | Applied to Skin | Applied to Skin | Topical |
Active Ingredient(s) | Imidacloprid/Pyriproxyfen | Fipronil/(S)-Methoprene | Dinotefuran, Pyriproxyfen, Permethrin |
RX Required |
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Dosage | Monthly | ||
Usage |
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Video | Coming soon | Coming soon | Coming soon |
Vet Review | The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats. I find that advantage kills fleas and larvae more quickly than some of the other products out there, often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years. The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks. It also does not control ticks as well on dogs and cats. I find that advantage works most effectively when combined with good environmental flea control at home. | I find that the effective combination of an ingredient like fipronil, along with the insect growth regulator methoprene, provides the best spectrum of activity and protection against all stages of the flea life cycle from egg through larval stage on to adult. Because of these two main ingredients and their method of action, I find that clients don't have to treat the environment as much. I find that this product tends to be safer in smaller breed animals when compared to its competition. I find its tick efficacy quite good. The fact that it is waterproof also allows clients, whose pets swim frequently, to confidently use this product during the swimming months. I also find that this product works the longest for fleas, while some of the competitive products have to be reapplied before the end of the month. The lack of label efficacy against mosquitoes and flies, as well as the fact that this product does not repel fleas or ticks are the two main disadvantages. As with any insecticidal products, I find that every pet is an individual, in terms of which of the products works best on them. When I am dealing with more of a flea issue in a patient, this is the product I will likely reach for first. | For clients that prefer an outstanding topical medication that has thus far had an excellent record of efficacy against both fleas and ticks. This product includes 3 very powerful and synergistic flea/tick pesticides that work in slightly different ways, with one preventing development of flea eggs and larvae, while another ingredient quickly kills; killing probably the fastest of any products on the market, starting to act within 5 minutes. Ticks will take somewhat longer, but within 2 days most ticks are killed. The addition of the permethrin ingredient does add the benefit of this product in BOTH repelling and killing ticks, , as well as the additional benefit of killing and repelling mosquitoes, the main vectors of heartworm disease in dogs and cats. As with other topicals, occasionally pets will develop an irritation or sensitivity at the sight of application, with some pets being occasionally restless, agitated, or fidgety. On rare occasions vomiting and/or diarrhea may be seen but this has not been much of a problem in clinical practice, where most pets seem to tolerate the product quite well. While the trio of main ingredients in this product seem to provide additional efficacy and coverage of various stages of the external parasites, including the benefit of repelling them, I am always a bit cautious about combination products like this, which rarely may lead to unknown chronic side effects that we are not yet aware of. With that consideration, this product is still an excellent and effective choice. I give this product an overall rating of 4 out of 5. |