Advantage II vs. Frontline Plus Comparison

Advantage II

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Frontline Plus

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Revolution

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Kills Fleas

Repels Fleas

Kills Flea eggs and Larvae

Prevents development

Kills Ticks

Repels Ticks

Kills and/or Repels Mosquitoes

Prevents Heartworm

Other Parasites Information

Treats, Prevents, and Controls Lice Infestations

Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation

Controls ear mites, roundworms and hookworms.

Waterproof (shampooing once a week can reduce effectiveness)

Safe for pregnant or nursing Pets

Consult your veterinarian

How long does it take to work

Kills fleas in 12 hours

Kills Fleas within 12 hours and Ticks within 48 hours

See a greater than 90% control of your flea infestation during the first month but because adult fleas will emerge from cocoons in your environment, you may see a few fleas for several months until the flea population is destroyed.

Taste

Applied to Skin

Active Ingredient(s)

Imidacloprid/Pyriproxyfen

Fipronil/(S)-Methoprene

Selamectin

RX Required

Dosage

Monthly

Usage

Video

Coming soon

Vet Review

The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats.I find that advantage kills fleas and larvae more quickly than some of the other products out there, often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years. The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks. It also does not control ticks as well on dogs and cats. I find that advantage works most effectively when combined with good environmental flea control at home.

I find that the effective combination of an ingredient like fipronil, along with the insect growth regulator methoprene, provides the best spectrum of activity and protection against all stages of the flea life cycle from egg through larval stage on to adult. Because of these two main ingredients and their method of action, I find that clients don't have to treat the environment as much. I find that this product tends to be safer in smaller breed animals when compared to its competition. I find its tick efficacy quite good. The fact that it is waterproof also allows clients, whose pets swim frequently, to confidently use this product during the swimming months. I also find that this product works the longest for fleas, while some of the competitive products have to be reapplied before the end of the month. The lack of label efficacy against mosquitoes and flies, as well as the fact that this product does not repel fleas or ticks are the two main disadvantages. As with any insecticidal products, I find that every pet is an individual, in terms of which of the products works best on them. When I am dealing with more of a flea issue in a patient, this is the product I will likely reach for first.

This versatile topical product has the widest range of protection of both internal and external parasites. In both cats and dogs, all 3 stages of the flea life cycle are effectively controlled,in addition to ear mites. For dogs, there is also the wonderful treatment benefit of killing hidden scabies mites on the skin, which are so difficult for veterinarians to find on routine skin scrapings at our offices. In fact, when either I or veterinary dermatologists are presented with a very itchy dog, in addition to our allergy workups, we will often treat with this topical every few weeks to treat and rule out any hidden scabies mites contributing to the pet's itching. It is amazing how many dogs will respond to this treatment, leading me to believe that scabies mites are involved with a lot more itching problems in dogs than I first learned about in vet school. With the increased recognition and understanding of feline heartworm disease, this is often the first heartworm preventative that I will reach for in cats, especially given all of the other benefits above. While it is often effective for canine heartworm prevention as well, I have heard of rare lapses in protection, so I usually combine this topical in dogs with one of the oral heartworm prevention medications like Heartgard or Interceptor. The only disadvantage I have seen is the rare reaction on cats of mild digestive upset and temporary hair loss at the site of application. It also has the wonderful benefits of being water proof in only 2 hours after application, and in being approved for use in puppies as young as 6 weeks of age.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.