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Kills Fleas |
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Repels Fleas |
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Kills Flea eggs and Larvae |
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Prevents Development |
Kills Ticks |
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Repels Ticks |
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Kills and/or Repels Mosquitoes |
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Prevents Heartworm |
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Other Parasites Information | NA |
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Controls adult hookworms and removes and controls adult roundworms & whipworms |
Waterproof (shampooing once a week can reduce effectiveness) |
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N/A |
Safe for pregnant or nursing Pets |
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Consult your veterinarian |
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How long does it take to work | Reapply every 30 days. | 1 day | Begins to work Immediately, However, pre-existing flea populations may continue to develop and emerge. |
Taste | Applied to skin | Applied to Skin | Beef Flavor |
Active Ingredient(s) | Indoxacarb, Permethrin | Amitraz | Milbemycin Oxime/Lufenuron |
RX Required |
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Dosage | |||
Usage |
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Video | Coming soon | Coming soon | Coming soon |
Vet Review | When the Activyl product line came out several years ago, it was touted as a totally novel new product on the market that would not have the problems of emerging flea resistance to products that has believed to been increasing in recent years with the old standby products in some cases. It supposedly works through a unique process of bioactivation using only the flea enzymes in activating the main ingredient, indoxacarb, in killing fleas. Along with the permethrin ingredient for tick coverage and control, it would seem like this would be a first line or excellent choice for those looking for a novel and comprehensive flea/tick product for their dogs. And while it is also effective in preventing flea eggs and larvae from developing as well, and can be highly effective in today's war against fleas and ticks, I have seen occasional problems with this product, as reported by clients. While its deeper penetration in the fatty oils of the skin may be a benefit, and while the product is not reported to be absorbed systemically, I have seen occasional and severe side effects reported by animal guardians. As with most other topical products in this venue, this particular product can occasionally cause irritation and itching at the site of application, which while usually only transient for a day or two, in some pets the itching and allergic reaction has been noted to intensify, necessitating anti-itch medications for relief. Some clients have also reported an odd odor from the application site for a while, as well as an oily film, which may persist for a few days. While many clients do report this product highly effective when other competitor products may have failed them recently, these occasional reactions are important to note, especially in a very sensitive or geriatric animal, and/or one with a chronic medical condition. On very rare occasions, clients have reported digestive side effects, as well as rare neurological weakness, stiffness or even spasms. While the vast majority of clients are satisfied with this product's performance and reliability, the decision on using this stronger, newer way of flea and tick control, should be made after careful consideration of patient history, as well as discussion with the local veterinarian. I give this product an overall rating of a 4, with an ease of use of a 5, with a mid-rating safety level of 3. | This is one of my favorite and most effective products in preventing tick infestations on dogs of all sizes, as well as preventing the tick born diseases such as Lyme disease, Rocky Mountain Spotted Fever, Ehlrichia and Anaplasmosis. When some of the topical products have failed in some patients, I have found this collar quite valuable in significantly cutting down on tick burdens in these dogs. The effects are long lasting for up to 3 months preventing ticks from even attaching to dogs, and thus cutting down on tick exposure to humans as well. The only problems in terms of efficacy I have even seen with this product is when animal guardians apply the collar too loosely to their pets, which can cut down on its efficacy against ticks.. In order for this collar to work effectively, it must be fitted snugly against the pet's neck, where one is just able to get two fingers under the collar. If the collar is applied too loosely I have occasionally seen pets ingest this collar, leading to serious systemic reactions. The only other downside in using this collar is if the pet spends a significant time swimming during the warmer months. The collar's efficacy is cut down significantly if it is submerged in water or exposed to drenching rains. However when properly fitted to a dog's neck, this is one of the most effective products in preventing tick infestations on the market. | Sentinel is a wonderful combination of the heartworm prevention pill interceptor and the flea control product program both in this one pill. Many clients enjoy the convenience of having such broad acting internal and external parasites in one pill, without having to worry about giving two separate medicines. Lufenuron, which is the main flea control ingredient, stops the flea life cycle in its track at the egg and larval stage, thus being like a birth control pill for fleas who get on our pets. Given that the main problem of fleas is how rapidly they reproduce, this pill literally stops escalating growth of flea populations, before they can become established in our homes, where most of the flea life cycle occurs. The main disadvantage to this product is that it does not kill or repel adult fleas, so in situations with already established heavy infestations, it is best combined with a great topical product like advantage or front line or with the oral adulticide flea pill Capstar for maximal effect. The only other rare disadvantage I see is the slight increase in reactions when two products are combined into one like this, but fortunately this is not common in clinical practice. With milbemycin for prevention of heartworms and controlling and treating most common intestinal worms, I overall highly recommend this versatile product. |