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| Kills Fleas |
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| Repels Fleas |
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| Kills Flea eggs and Larvae |
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| Kills Ticks |
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| Repels Ticks |
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| Kills and/or Repels Mosquitoes |
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| Prevents Heartworm |
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| Other Parasites Information | Advantage XD kills lice, but does not treat any internal parasites like heartworms or intestinal worms. | Repels and prevents blood-feeding by biting flies and kills chewing lice. | |
| Waterproof (shampooing once a week can reduce effectiveness) | Yes, Advantage XD is waterproof. Do not bathe your cat or allow them to get wet for at least 24 hours after applying Advantage® XD. Frequent shampooing can reduce effectiveness. See product label for more information. |
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| Safe for pregnant or nursing Pets | Consult your veterinarian for pregnant or nursing cats. | Consult your veterinarian | |
| How long does it take to work | 30 minutes to 4 hours. | Kills Fleas 12 hours | Within 24 hours |
| Taste | Not applicable (topical treatment). | Applied to Skin | Applied to Skin |
| Active Ingredient(s) | Spinetoram | Imidacloprid/ Permethrin/Pyriproxyfen | Fipronil, (S)-Methoprene |
| RX Required |
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| Dosage | Apply one applicator every 2 months. | ||
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| Video | Coming soon | Coming soon | Coming soon |
| Vet Review |
The fast-acting nature of Advantage XD is one of its standout features, as it starts killing fleas within 30 minutes to 4 hours, providing rapid relief for cats. Its long-lasting formula is another major benefit, offering protection for up to two months per application, which is twice the duration of many other flea treatments. The active ingredient, spinetoram, is derived from natural soil microbes, making it a preferred option for veterinarians concerned about using harsh chemicals on sensitive pets. However, as with any topical treatment, some cats may experience mild skin reactions like irritation or hair loss at the application site. Despite this, Advantage XD remains a top choice for its effectiveness and ease of use, though in cases of severe infestations, veterinarians may recommend additional environmental flea control measures. |
I love the broad acting antiparasitic effects of this product, which covers protection against a wider variety of pests to our pets than the competition. I feel it works the quickest in terms of flea/tick killing, and I love the fact that it repels fleas and ticks as well. Given that we are uncovering new and emerging tick born diseases, I prefer a product that repels in addition to quickly killing ticks, as well, and thus prevents tick attachment and transmission of disease. We are also now recognizing that mosquitoes can transmit diseases like West Nile virus to dogs, and so the added protective benefit of Advantix on mosquitoes and flies makes it quite attractive, especially for those clients whose pets spend a lot of time outside in the yard in the warmer months, when flies are most active. With this product I see much less fly strike and maggot infestation of outside dogs because of this added benefit. By repelling mosquitoes, we also get less transmission of potential heartworms to dogs. I have found that some smaller breeds of dogs are sometimes sensitive to the permethrin ingredient in this product, occasionally becoming excessively sensitive after application. I also find that although the product is labelled as water proof, on those pets, who are frequently bathed or swimming for long periods, that the product may need to be applied more frequently than once monthly. Some clients also find it somewhat more inconvenient in larger breeds having to apply the product in several spots, rather than in a single spot like its competitor. |
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors.
The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
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