Advantage XD vs. Advantage Yard & Premise Spray Comparison

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Advantage XD

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Advantage Yard & Premise Spray

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Cheristin For Cats

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Kills Fleas

Repels Fleas

Kills Flea eggs and Larvae

Kills Ticks

Repels Ticks

Kills and/or Repels Mosquitoes

Prevents Heartworm

Other Parasites Information

Advantage XD kills lice, but does not treat any internal parasites like heartworms or intestinal worms.

Waterproof (shampooing once a week can reduce effectiveness)

Yes, Advantage XD is waterproof. Do not bathe your cat or allow them to get wet for at least 24 hours after applying Advantage® XD. Frequent shampooing can reduce effectiveness. See product label for more information.

Safe for pregnant or nursing Pets

Consult your veterinarian for pregnant or nursing cats.

Consult with your veterinarian before using this product on debilitated, aged, pregnant or nursing animals.

How long does it take to work

30 minutes to 4 hours.

Starts killing fleas in 30 minutes, and kills 98-100% of fleas in 12 hours.

Taste

Not applicable (topical treatment).

Topical application

Active Ingredient(s)

Spinetoram

RX Required

Dosage

Apply one applicator every 2 months.

Usage

Video

Coming soon

Vet Review

The fast-acting nature of Advantage XD is one of its standout features, as it starts killing fleas within 30 minutes to 4 hours, providing rapid relief for cats. Its long-lasting formula is another major benefit, offering protection for up to two months per application, which is twice the duration of many other flea treatments. The active ingredient, spinetoram, is derived from natural soil microbes, making it a preferred option for veterinarians concerned about using harsh chemicals on sensitive pets. However, as with any topical treatment, some cats may experience mild skin reactions like irritation or hair loss at the application site. Despite this, Advantage XD remains a top choice for its effectiveness and ease of use, though in cases of severe infestations, veterinarians may recommend additional environmental flea control measures.

Fleas are easily the most common external parasite that plague cats throughout the country. Fleas have been shown to not only cause weakness and anemia in affected cats, but also transmit dangerous infectious diseases, including bartonellosis, an also increasing threat to humans. Cheristin is made with the same main ingredient as Comfortis for cats, and acts uniquely on the nervous system of the flea. Unlike flea prevention tablets, Cheristin starts killing fleas within 30 minutes and almost 100 percent of fleas within 12 hours. With the easy to use applicator, this product has been shown to be quite effective for one month. The most common, yet rare side effect I have seen in cats is an allergic reaction or hair loss at the site of application, and even less commonly vomiting and lethargy. It is an excellent and fast acting, effective product with an overall rating of a 4.5 with an ease of administration of a 5.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.