NEW CUSTOMERS SAVE 40% W/AUTOSHIPUse code NEW40 (Up to $30 max. Exclusions apply)
SAVE AN EXTRA $5 - $20 OFFUse code PETS in cart (Exclusions apply)
Kills Fleas |
![]() |
![]() |
![]() |
Repels Fleas |
![]() |
![]() |
![]() |
Kills Flea eggs and Larvae |
![]() |
N/A | Prevents Development |
Kills Ticks |
![]() |
![]() |
![]() |
Repels Ticks |
![]() |
![]() |
![]() |
Kills and/or Repels Mosquitoes |
![]() |
![]() |
![]() |
Prevents Heartworm |
![]() |
![]() |
![]() |
Other Parasites Information | Treats, Prevents, and Controls Lice Infestations | N/A | Controls adult hookworms and removes and controls adult roundworms & whipworms |
Waterproof (shampooing once a week can reduce effectiveness) |
![]() |
N/A | N/A |
Safe for pregnant or nursing Pets | Consult your veterinarian | The safe use of Credelio in breeding, pregnant or lactating dogs hasn't been evaluated. |
![]() |
How long does it take to work | Kills fleas in 12 hours | Credelio starts killing fleas within 4 hours of administration and kills over 99% of fleas within 8 hours of administration. | Begins to work Immediately, However, pre-existing flea populations may continue to develop and emerge. |
Taste | Applied to Skin | Beef-flavored chewable | Beef Flavor |
Active Ingredient(s) | Imidacloprid/Pyriproxyfen | Lotilaner | Milbemycin Oxime/Lufenuron |
RX Required |
![]() |
![]() |
![]() |
Dosage | |||
Usage |
![]() |
![]() |
![]() |
Video | Coming soon | Coming soon | Coming soon |
Vet Review | The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats. I find that advantage kills fleas and larvae more quickly than some of the other products out there, often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years. The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks. It also does not control ticks as well on dogs and cats. I find that advantage works most effectively when combined with good environmental flea control at home. | Belonging to the latest generation of flea/tick parasiticides(known as Isoxazoline medications), these palatable, beef flavored chewable tablets kills fleas quite effective, with most adult fleas being killed within 8 hours. One of the downsides, as compared with Vectra 3D is that Credilio does not repel either fleas or ticks, and has no effect on biting mosquitoes, which are the main vectors that transmit heartworms to dogs. Credilio and products of its class are one of the most effective products against several species of severe disease transmitting ticks, including ones that transmit Lyme Disease, Ehrlichiosis, Rocky Mountain Spotted Fever and Anaplasmosis, which have been increasing in incidence in recent years. As with other members of this drug class, we have also used this drug in treatment and prevention of both demedex mites and scabies mites, although this is an off label use. Giving with a full meal reduces risks of digestive reaction. Overall the tablet is well tolorated, but occasional diarrhea, vomiting or digestive upset is seen. I would look to one of the other products like Vectra 3D, if there is a history of significant neurologic disease or seizures. I give this product an overall rating of a 4 out of 5. | Sentinel is a wonderful combination of the heartworm prevention pill interceptor and the flea control product program both in this one pill. Many clients enjoy the convenience of having such broad acting internal and external parasites in one pill, without having to worry about giving two separate medicines. Lufenuron, which is the main flea control ingredient, stops the flea life cycle in its track at the egg and larval stage, thus being like a birth control pill for fleas who get on our pets. Given that the main problem of fleas is how rapidly they reproduce, this pill literally stops escalating growth of flea populations, before they can become established in our homes, where most of the flea life cycle occurs. The main disadvantage to this product is that it does not kill or repel adult fleas, so in situations with already established heavy infestations, it is best combined with a great topical product like advantage or front line or with the oral adulticide flea pill Capstar for maximal effect. The only other rare disadvantage I see is the slight increase in reactions when two products are combined into one like this, but fortunately this is not common in clinical practice. With milbemycin for prevention of heartworms and controlling and treating most common intestinal worms, I overall highly recommend this versatile product. |