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| Kills Fleas |
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| Repels Fleas |
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| Kills Flea eggs and Larvae | N/A |
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Prevents all flea stages (eggs, pupae, larvae, and adult fleas) from developing. |
| Kills Ticks |
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| Repels Ticks |
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| Kills and/or Repels Mosquitoes |
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| Prevents Heartworm |
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| Other Parasites Information | Protects against 5 types of ticks, roundworms, and hookworms | Treats and controls hookworms, roundworms, and whipworms infections. | Also kills biting and sand flies, live and mites for one month |
| Waterproof (shampooing once a week can reduce effectiveness) | N/A | N/A |
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| Safe for pregnant or nursing Pets | The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs. | Consult your veterinarian |
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| How long does it take to work | It starts to kill deer ticks within 8 hours, and fleas within 4 hours | Starts to kill fleas within 30 minutes; kills 100% of fleas within 4 hours. | Starts to reduce flea feeding in just 5 minutes |
| Taste | liver-flavored chewable tablet | Beef Flavor | Topical |
| Active Ingredient(s) | Sarolaner, moxidectin, and pyrantel | Spinosad/Milbemycin Oxime | Dinotefuran, Pyriproxyfen, Permethrin |
| RX Required |
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| Dosage | Monthly | ||
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| Video | Coming soon | Coming soon | Coming soon |
| Vet Review | Coming soon | An exciting and brand new product now available combines the main ingredient of Interceptor milbemycin with a powerful flea insecticide known as spinosad. Given as a once monthly heartworm preventative, this product also will control and prevent whipworms, hookworms and roundworms, in addition to preventing heartworms. The additional ingredient spinosad allows effective flea and these internal parasite control all in one pill, making it quite convenient for clients. As with any pesticide rare digestive tract and neurological side effects may occur but this has not been a major problem in clinical trials. Since it is relatively new I will have to see how this product performs on the fleas but it seems to have excellent potential. I give this product an overall rating of a 5 with an ease of administration a 5 as well, taste a 5. | For clients that prefer an outstanding topical medication that has thus far had an excellent record of efficacy against both fleas and ticks. This product includes 3 very powerful and synergistic flea/tick pesticides that work in slightly different ways, with one preventing development of flea eggs and larvae, while another ingredient quickly kills; killing probably the fastest of any products on the market, starting to act within 5 minutes. Ticks will take somewhat longer, but within 2 days most ticks are killed. The addition of the permethrin ingredient does add the benefit of this product in BOTH repelling and killing ticks, , as well as the additional benefit of killing and repelling mosquitoes, the main vectors of heartworm disease in dogs and cats. As with other topicals, occasionally pets will develop an irritation or sensitivity at the sight of application, with some pets being occasionally restless, agitated, or fidgety. On rare occasions vomiting and/or diarrhea may be seen but this has not been much of a problem in clinical practice, where most pets seem to tolerate the product quite well. While the trio of main ingredients in this product seem to provide additional efficacy and coverage of various stages of the external parasites, including the benefit of repelling them, I am always a bit cautious about combination products like this, which rarely may lead to unknown chronic side effects that we are not yet aware of. With that consideration, this product is still an excellent and effective choice. I give this product an overall rating of 4 out of 5. |
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors.
The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
Note: Any trademarks are the property of their respective companies.
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