Advantage II vs. Frontline Plus Comparison

Advantage II

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Frontline Plus

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NexGard for Dogs Chewables

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Kills Fleas

Repels Fleas

Kills Flea eggs and Larvae

Kills fleas before they can lay eggs

Kills Ticks

Repels Ticks

Kills and/or Repels Mosquitoes

Prevents Heartworm

Other Parasites Information

Treats, Prevents, and Controls Lice Infestations

Eliminates infestations with chewing lice, aids in the control of sarcoptic mange infestation

Waterproof (shampooing once a week can reduce effectiveness)

N/A

Safe for pregnant or nursing Pets

Consult your veterinarian

The safe use of NexGard in pregnant, breeding or lactating dogs has not been evaluated.

How long does it take to work

Kills fleas in 12 hours

Kills Fleas within 12 hours and Ticks within 48 hours

NexGard kills 100% of fleas within 24 hours.

Taste

Applied to Skin

Beef-flavored chewable

Active Ingredient(s)

Imidacloprid/Pyriproxyfen

Fipronil/(S)-Methoprene

Afoxolaner

RX Required

Dosage

Monthly

Usage

Video

Coming soon

Vet Review

The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats.I find that advantage kills fleas and larvae more quickly than some of the other products out there, often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years. The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks. It also does not control ticks as well on dogs and cats. I find that advantage works most effectively when combined with good environmental flea control at home.

I find that the effective combination of an ingredient like fipronil, along with the insect growth regulator methoprene, provides the best spectrum of activity and protection against all stages of the flea life cycle from egg through larval stage on to adult. Because of these two main ingredients and their method of action, I find that clients don't have to treat the environment as much. I find that this product tends to be safer in smaller breed animals when compared to its competition. I find its tick efficacy quite good. The fact that it is waterproof also allows clients, whose pets swim frequently, to confidently use this product during the swimming months. I also find that this product works the longest for fleas, while some of the competitive products have to be reapplied before the end of the month. The lack of label efficacy against mosquitoes and flies, as well as the fact that this product does not repel fleas or ticks are the two main disadvantages. As with any insecticidal products, I find that every pet is an individual, in terms of which of the products works best on them. When I am dealing with more of a flea issue in a patient, this is the product I will likely reach for first.

Within the past year there has been an exciting development in the battle against fleas and ticks.For years, veterinarians have relied on topical medications for control of fleas and ticks, however many formulations are greasy, as well as some sensitive pets may have an allergic reaction to contact some of them. Many clients also worry about the exposure of humans to topical flea and tick pesticides. That is why the exciting new product from Merial known as Nexgard has been such a welcome addition to our flea and tick treatment and prevention options. By using a the ingredient, afoxolaner, Merial has come out with a new product that most fleas and ticks are certainly susceptible. Dogs also LOVE the soft, beef flavored chewable, even without meals. It has also been shown to be safe at up to 5 times the recommended dose.The only down side to this product is that the parasites must bite the dog to be affected, and in some cases this may take up to many hours for this to occur. However, studies as well as clinical experience with this product show that is it very effective in preventing Lyme, Anaplasmosis, Ehrlichiosis and Rocky Mountain spotted fever. This makes it essential as part of any year round parasite prevention program in our dogs. The only rare side effects I have seen are mild digestive upset. I therefore give this product an overall rating of a 4.5, with an ease of use of a 5 out of 5.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.