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| Reduces Pain and Inflammation associated with Arthritis? |
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| Reduces Fever? |
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| Reduces Joint Stiffness? |
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| Controls Symptoms of Osteoarthritis |
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| Additional Benefits | Can also reduce pain associated with surgery or dental procedures | Targets canine osteoarthritis pain and inflammation while reducing the impact on GI, kidney, and liver homeostasis. | Also relieves pain and inflammation from hip dysplasia |
| What Makes it Different? | Blocks COX-2 enzymes trigger inflammation and contribute to pain in arthritic joints | Galliprant (grapiprant tablets) is a first-in-class non-COX-inhibiting prostaglandin receptor antagonist. It specifically blocks the EP4 receptor, the primary mediator of canine osteoarthritis pain and inflammation. Galliprant (grapiprant tablets) does not inhibit the production of many housekeeping prostanoids that maintain homeostatic functions. | Generic equivalent to Rimadyl, comes in chewable tablet or caplet form |
| Recommended For? | Dogs | Dogs (9 months of age or older, weighing 8 lbs or more) | Dogs (Over 6 weeks of age) |
| Product Type | Chewable Tablet | Tablet | Chewable Tablet |
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| RX Required |
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| How Long does it Take to Work? | Within Hours of Dose | Within Hours of Dose | Within Hours of Dose |
| Video | |||
| Ingredients | Deracoxib | Grapiprant | Carprofen |
| Does it have long-term side effects? | Danger of serious damage to healthy by prolonged exposure if swallowed. May possibly affect kidneys, gastrointestinal tract, development and/or reproduction | In a 9-month toxicity study, vomiting and soft-formed or mucus stool were observed in all groups, including controls, with higher incidence in grapiprant-treated dogs. Decreases in serum albumin and total protein were seen with increasing doses of grapiprant. Hypoalbuminemia and hypoproteinemia were reversible when treatement was discontinued. Three treated dogs and one control dog had elevated alkaline phosphatase values. | Laboratory studies in anesthetized dogs and clinical field studies have demonstrated that carprofen is well tolerated in dogs after oral administration. |
| Cautions | Do not use with aspirin, another NSAID such as etodolac, carprofen, or piroxicam, an over-the-counter cough, cold, allergy, or pain medication, warfarin, furosemide, an ACE inhibitor such as enalapril, a steroid such as prednisone, insulin, or probenecid. | Galliprant (grapiprant tablets) is for use in dogs 9 months of age or older, weighing 8 lbs or more only. Do not use in cats. Galliprant (grapiprant tablets) are not for use in humans. Keep this and all medications out of reach of children and pets. Consult a physician in case of accidental ingestion by humans. Store Galliprant (grapiprant tablets) out of reach of dogs and other pets in a secured location in order to prevent accidental ingestion or overdose. | Contact the veterinarian if the pet has bloody, black or tarry stools, blood in vomit, or swelling or rapid weight gain due to fluid retention. Do not use on cats. |
| What are Customers saying Pros | Betty is an 8 year old Rotty with the typical old Rotty joint and movement issues. Deramaxx makes such a difference in her pain management and happiness level. She is able to jump and bound like a 5 year old Rotty again. Deramaxx will be with us until the end. | I cannot say enough how great this med is. My lab’s pain was so bad that I thought she had experienced a stroke…..she couldn’t walk without help, and her face and eyes showed confusion and pain. After one pill, she began to feel better and in less than 24 hours she was back to her normal self. I was afraid I was going to lose her, but this med has brought her back to me. It is a miracle worker. | My poor old Lady and I share problems getting up and down ... the Novox has really helped her. Wish I could take some! (Just kidding, of course.) It really has made a difference in her mobility - and her disposition. Thanks! |
| What are Customers saying Cons | ...his liver values came up and now his kidneys are in failure. | From a helping stand point it's perfect; he’s so much better…from a money standpoint, saddening this is so expensive. | ...will not take Novox...I don't know if it has a bitter taste..."...may cause kidney failure. |
| Vet Recommendations | This close relative of the human arthritic drug celebrex, which has helped so many suffering human arthritis patients, has really shined in its veterinary use. All nonsteroidal anti inflammatory drugs on the market to varying degrees block enzymes in our pets bodies involved with pain and inflammation. The deramaxx difference and advantage is that unlike many competitor products, deramaxx does NOT block enzymes that are involved in blood clotting, protection of the stomach lining and kidney function, thus providing an increased balance of safety and efficacy over other products I have seen in practice. Deramaxx specifically targets the source of osteoarthritis inflammation and pain with ONE chewable tablet controlling inflammation for a full 24 hours. This FDA approved drug has been prescribed to over one million dogs over the past 2 years. One study with one of its major competitors, showed that lame dogs put more weight on the leg quicker and for longer periods than another drug of its class commonly prescribed. As with any individual drug of the nonsteroidal anti inflammatory class, there can be very rare reactions involving the digestive tract, kidneys or liver. I find that when we do complete blood and urine workups on pets before starting on this medication, that we are able to prescribe drugs like this more safely. For those pets who need deramaxx long term, blood work should be done every 4-6 months in my opinion. I often find that when using the wonderful neutraceuticals from 1800petmeds for arthritis like super joint enhancer, proanthozone, and super joint omega that I am able to use much lower doses of deramaxx in controlling chronic degenerative joint disease and arthritis in many of our aging dogs,, even only a dose or two a week in some cases, once the neutraceuticals take effect over several weeks. For some of the major orthopedic procedures done on dogs today, including fracture repair, joint reconstruction, and the ever increasing number of cruciate surgeries being done on dogs, that deramaxx offers superior relief and quicker return to function than some of the other competitor products. The main disadvantages I have found is the lack of an approved injectable medication for same day use in my surgery cases, as well as the lack of FDA labelled safety and approval for use in young puppies.6 weeks of age. Also it is so important for clients to review with their veterinarians any prior drug or antibiotic reactions, ot the use of any other over the counter drugs, other prescription medicines, as well as nutritional supplements that could interact with drugs of this class and potentially lead to increased complications. These issues should always be discussed with your vet on case by case basis, but by no means should discourage the use of this wonderful often life saving drug... | There has been an exciting development in the area of pain management in the past year. The recognition, understanding, and use of pain management medications in veterinary medicine has grown dramatically, especially for osteoarthritis in dogs. Over the past 20 years, improved nonsteroidal anti-inflammatory medications such as Rimadyl, Metacam, Deramaxx, and Previcox, have indeed been great helps in managing pain and inflammation in arthritic patients, however, there remain risks in occasional, sensitive animals of serious side effects, whether it be on the digestive tract, kidneys or liver. With the arrival of the new drug Galliprant, conventional veterinarians now have a unique and innovative product that targets the clinical signs(i.e pain, inflammation) of arthritis by specifically blocking a particular receptor, while sparing other similar receptors to continue, do help with balance and health. Therefore there are much fewer risks of especially kidney and liver dysfunction. While GI side effects can occasionally occur, they are much rarer and milder than with many nonsteroidal anti-inflammatory medications and can be minimized by giving with food. The medication starts working within the day, but more typical is gradual improvement over the first month of therapy. While veterinarians are still gaining clinical experience in this newly approved drug, the main side effect rarely encountered is short lived vomiting, which typically resolves on its own. Even rarer are loose, mucoid stools. An outstanding benefit of this novel product is that it can be used in animals as young as one year of age. It also comes in a very palatable pork liver flavor formulation. I give this medication an overall rating of a 4.5. | Currently under review |
Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors.
The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.
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