Galliprant vs. Prednisolone Comparison

Galliprant

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Prednisolone

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Previcox

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Reduces Pain and Inflammation associated with Arthritis?

Reduces Fever?

Reduces Joint Stiffness?

Controls Symptoms of Osteoarthritis

Additional Benefits

Targets canine osteoarthritis pain and inflammation while reducing the impact on GI, kidney, and liver homeostasis.

Remedies swelling and itchy skin caused by allergies

Can also be given to dogs 2 hours before surgery

What Makes it Different?

Galliprant (grapiprant tablets) is a first-in-class non-COX-inhibiting prostaglandin receptor antagonist. It specifically blocks the EP4 receptor, the primary mediator of canine osteoarthritis pain and inflammation. Galliprant (grapiprant tablets) does not inhibit the production of many housekeeping prostanoids that maintain homeostatic functions.

Only comes in a 5mg tablet

Comes in a flavored chewable tablet for easy administration

Recommended For?

Dogs (9 months of age or older, weighing 8 lbs or more)

Dogs & Cats

Dogs (7 weeks of age or older)

Product Type

Tablet

Chewable Tablet

Usage

RX Required

How Long does it Take to Work?

Within Hours of Dose

Video

Ingredients

Grapiprant

Prednisolone

Firocoxib

Does it have long-term side effects?

In a 9-month toxicity study, vomiting and soft-formed or mucus stool were observed in all groups, including controls, with higher incidence in grapiprant-treated dogs. Decreases in serum albumin and total protein were seen with increasing doses of grapiprant. Hypoalbuminemia and hypoproteinemia were reversible when treatement was discontinued. Three treated dogs and one control dog had elevated alkaline phosphatase values.

Cushing's Syndrome in dogs has been reported in association of prolonged or repeated steroid therapy

The vast majority of patients with drug related adverse reactions have recovered when the signs are recognized, the drug is withdrawn, and veterinary care, if appropriate, is initiated. Owners should be advised of the importance of periodic follow up for all dogs during administration of any NSAID.

Cautions

Galliprant (grapiprant tablets) is for use in dogs 9 months of age or older, weighing 8 lbs or more only. Do not use in cats. Galliprant (grapiprant tablets) are not for use in humans. Keep this and all medications out of reach of children and pets. Consult a physician in case of accidental ingestion by humans. Store Galliprant (grapiprant tablets) out of reach of dogs and other pets in a secured location in order to prevent accidental ingestion or overdose.

Without first talking to your veterinarian, dp not give your pet any over-the-counter or other prescription medications while giving prednisone. There are possible side effects, including insomnia, nausea, vomiting, upset stomach, and fatigue.

Do Not Give To Cats

What are Customers saying Pros

I cannot say enough how great this med is. My lab’s pain was so bad that I thought she had experienced a stroke…..she couldn’t walk without help, and her face and eyes showed confusion and pain. After one pill, she began to feel better and in less than 24 hours she was back to her normal self. I was afraid I was going to lose her, but this med has brought her back to me. It is a miracle worker.

... a small price to pay for the rest of her skin to be doing so good.

Our 11 year old Beagle was born with a left shoulder, joint deformity. AS she advanced in years, difficulity in walking resulted. Previcox restored normal joint movement and walking in two days.

What are Customers saying Cons

From a helping stand point it's perfect; he’s so much better…from a money standpoint, saddening this is so expensive.

...it started to have a negative effect on kitty.

After one day of taking it he started vomiting and had severe diarrhea...

Vet Recommendations

There has been an exciting development in the area of pain management in the past year. The recognition, understanding, and use of pain management medications in veterinary medicine has grown dramatically, especially for osteoarthritis in dogs. Over the past 20 years, improved nonsteroidal anti-inflammatory medications such as Rimadyl, Metacam, Deramaxx, and Previcox, have indeed been great helps in managing pain and inflammation in arthritic patients, however, there remain risks in occasional, sensitive animals of serious side effects, whether it be on the digestive tract, kidneys or liver. With the arrival of the new drug Galliprant, conventional veterinarians now have a unique and innovative product that targets the clinical signs(i.e pain, inflammation) of arthritis by specifically blocking a particular receptor, while sparing other similar receptors to continue, do help with balance and health. Therefore there are much fewer risks of especially kidney and liver dysfunction. While GI side effects can occasionally occur, they are much rarer and milder than with many nonsteroidal anti-inflammatory medications and can be minimized by giving with food. The medication starts working within the day, but more typical is gradual improvement over the first month of therapy. While veterinarians are still gaining clinical experience in this newly approved drug, the main side effect rarely encountered is short lived vomiting, which typically resolves on its own. Even rarer are loose, mucoid stools. An outstanding benefit of this novel product is that it can be used in animals as young as one year of age. It also comes in a very palatable pork liver flavor formulation. I give this medication an overall rating of a 4.5.

Prednisolone is a drug I will usually only reach for joint pain and/or stiffness if other prescribed nonsteroidal anti inflammatory have failed to work. While cortisone like drugs such as prednisolone can work to reduce inflammation and pain quite quickly, I do worry about the weakening effect on the ligaments and bone when used long term. I will usually use prednisolone over prednisone in geriatric pets or pets with preexisting liver disease. When used long term, it is important to monitor blood work to check for organ toxicity. The biggest side effects seen are usually increased thirst/urination/appetite, and occasionally diarrhea and vomiting. It is also important to monitor for blood loss as well. I give this product an overall ranking of 3.5 out of 5.

Previcox is another effective prescription nonsteroidal anti inflammatory medication that has found favor among many veterinarians in recent years. Supposedly more friendly on the liver and kidneys than some of the other non steroidal anti inflammatory medications it is especially helpful in managing arthritis and pain in middle age and older dogs. I have only rarely seen digestive tract reactions when using this product. I give this an overall ranking of a 4 out of 5.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.