Activyl vs. Advantage II Comparison

Activyl

Learn More

Advantage II

Learn More

Credelio Chewable Tablets for Dogs

Learn More

Kills Fleas

Repels Fleas

Kills Flea eggs and Larvae

N/A

Kills Ticks

Repels Ticks

Kills and/or Repels Mosquitoes

Prevents Heartworm

Other Parasites Information

Treats, Prevents, and Controls Lice Infestations

N/A

Waterproof (shampooing once a week can reduce effectiveness)

N/A

Safe for pregnant or nursing Pets

Consult your veterinarian

The safe use of Credelio in breeding, pregnant or lactating dogs hasn't been evaluated.

How long does it take to work

Reapply Activyl every 30 days.

Kills fleas in 12 hours

Credelio starts killing fleas within 4 hours of administration and kills over 99% of fleas within 8 hours of administration.

Taste

Applied to skin

Applied to Skin

Beef-flavored chewable

Active Ingredient(s)

indoxacarb

Imidacloprid/Pyriproxyfen

Lotilaner

RX Required

Dosage

Usage

Credelio Chewable Tablets for Dogs Usage

Video

Coming soon

Vet Review

Another recently available new topical flea preventative for dogs and cats. This new product works by being activated by only the flea's enzyme systems into a flea specific mechanism which paralyzes and kills the adult flea. The company claims that it does not get into the blood stream, but stays only in the superficial skin layers of the pet. Any adult fleas which come into contact with this product are quickly killed so that fleas do not have to actually bite the pet, which is tremendously helpful in those flea-allergic pets, where it only takes a few flea bites to set off an extensive itchy allergic reaction. Another wonderful benefit of this product is that it is waterproof, which is especially helpful in those active outside pets who are exposed to rain or like to swim. This effective product starts working within 12 hours of application, where over 90% of adult fleas are killed. Another excellent benefit of this product is that it also inhibits the development of flea eggs and larvae in the environment, which is a big bonus since much of the flea life cycle occurs in the home environment. While Activyl is very safe and effective for most pets, I have seen occasional rare reactions in sensitive pets, which most commonly is seen as irritation or excessive itchiness at the site of application. While the company says that it is odorless, some of my clients have said that they do sense an odor within the first several days of application, as well as leaving an occasional oily film for the first day or two following application. This film, however usually quickly disappears. The only other very rare reactions include digestive upset and/or drooling/neurological reactions, and certainly if a pet has any chronic digestive weaknesses or history of seizures, etc then the local veterinarian should be consulted before applying the product. I give this product an overall rating of 4, with an ease of use of 4.

The non-greasy, non-odor formulation is a definite plus when used on sensitive patients, especially cats.I find that advantage kills fleas and larvae more quickly than some of the other products out there, often resulting in quicker relief of flea allergy dermatitis symptoms in dogs and cats. Overall I have found it quite safe and have seen the fewest topical or rare systemic reactions in my practice over the years. The main disadvantage I have found is that in heavy flea infestations that the efficacy may wear off in less than one month, necessitating some vets to recommend more frequent off label use of this product every few weeks. It also does not control ticks as well on dogs and cats. I find that advantage works most effectively when combined with good environmental flea control at home.

Belonging to the latest generation of flea/tick parasiticides(known as Isoxazoline medications), these palatable, beef flavored chewable tablets kills fleas quite effective, with most adult fleas being killed within 8 hours. One of the downsides, as compared with Vectra 3D is that Credilio does not repel either fleas or ticks, and has no effect on biting mosquitoes, which are the main vectors that transmit heartworms to dogs. Credilio and products of its class are one of the most effective products against several species of severe disease transmitting ticks, including ones that transmit Lyme Disease, Ehrlichiosis, Rocky Mountain Spotted Fever and Anaplasmosis, which have been increasing in incidence in recent years. As with other members of this drug class, we have also used this drug in treatment and prevention of both demedex mites and scabies mites, although this is an off label use. Giving with a full meal reduces risks of digestive reaction. Overall the tablet is well tolorated, but occasional diarrhea, vomiting or digestive upset is seen. I would look to one of the other products like Vectra 3D, if there is a history of significant neurologic disease or seizures. I give this product an overall rating of a 4 out of 5.

Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Note: Any trademarks are the property of their respective companies.