NEW CUSTOMERS SAVE 40% W/AUTOSHIPUse code NEW40 (Up to $30 max. Exclusions apply)
SAVE AN EXTRA $5 - $20 OFFUse code PETS in cart (Exclusions apply)
Kills Fleas |
![]() |
![]() |
![]() |
Repels Fleas |
![]() |
![]() |
![]() |
Kills Flea eggs and Larvae |
![]() |
Prevents Development |
![]() |
Kills Ticks |
![]() |
![]() |
![]() |
Repels Ticks |
![]() |
![]() |
![]() |
Kills and/or Repels Mosquitoes |
![]() |
![]() |
![]() |
Prevents Heartworm |
![]() |
![]() |
![]() |
Other Parasites Information | Controls ear mites, hookworms and roundworms. | Protects against heartworms, fleas, roundworms, hookworms, whipworms and tapeworms. |
![]() |
Waterproof (shampooing once a week can reduce effectiveness) |
![]() |
N/A | N/A |
Safe for pregnant or nursing Pets | Consult your veterinarian | The safety of Sentinel Spectrum has not been evaluated in dogs used for breeding or in lactating females. | The safe use of Simparica has not been evaluated in breeding, pregnant, or lactating dogs. |
How long does it take to work | Kills fleas within 12 hours. | Begins to work Immediately, | Begins to kill adult fleas within 3 hours and ticks within 8 hours of administration. |
Taste | Applied To Skin | Beef-flavored chewable | Liver flavor |
Active Ingredient(s) | Imidacloprid/Moxidectin | Milbemycin oxime, lufenuron, and praziquantel. | sarolaner |
RX Required |
![]() |
![]() |
![]() |
Dosage | |||
Usage |
![]() |
![]() |
![]() |
Video | Coming soon | Coming soon | Coming soon |
Vet Review | By combining imidacloprid and moxidectin, Advantage Multi offers the wonderful benefit of broad protection against BOTH common internal and external parasites in dogs and cats. An important area of coverage includes not only adult stages, but the immature stages of roundworms and hookworms, two parasites that are a risk to people if not prevented in our pets. It also treats and controls, and prevents whipworms, which are difficult to eradicate in both dogs and the environment. When applied monthly, it is almost 100 percent effective in preventing heartworm disease in dogs and cats. Additional benefits of treating scabies and demodectic mange and ear mites make this a very attractive product. All of this with the wonderful flea control benefits of the product advantage. The greatest benefit I see with this versatile product is that it takes the labor out of administering a myriad of medications to dogs to control these varied internal and external parasites. I also find that it kills the larval stages of fleas in the home surroundings of treated pets, which is a wonderful added benefit. I have on rare occasions seen topical irritation and sensitivity at the site of application, and even more scarce neurological reactions in hypersensitive pets. The only other downside would be the potential high cost of this product, as well as the need for clients to obtain a prescription from their veterinarian. Overall, however, I have found this product to be an excellent and safe all around internal and external parasite control manager in our dogs and cats. | There is an outstanding new comprehensive internal and external parasite control product called sentinel spectrum, which combines 3 excellent worming medications that treat and prevent a wide variety of parasites from heartworms, intestinal worms ranging from tapeworms to whipworms, as well as controlling flea infestations. That is 6 types of parasites controlled with one pill. That is a wonderful benefit of this product, along with the tastiest beef flavored tablet. The only down side to this product in my experience and opinion is that it does not kill or repel fleas, but breaks the flea life cycle by preventing adult fleas from laying eggs, as well as killing the eggs. Adult fleas still may bite your dog, which may cause allergic dermatitis in some sensitive animals. I have also seen occasional pet vomit on this product, which is usually avoided by giving with a meal. A wonderful benefit over topical parasite control measures is that by combining all of the wonderful ingredients into a pill formulation prevents exposure of the humans in the household to chemical pesticide residues. I give this product an overall rating of a 4, with a taste of 4 and ease of use of a 5. | Within the past few years, we have seen a surge of new flea and tick parasiticides for dogs and cats, especially important as we are discovering increased transmission of health-threatening disease to our animal companions. In the past year, the very trustworthy and reliable pharmaceutical company Zoetis has come out with a revolutionary liver flavored chewable tablet, Simparica, that is highly effective against fleas and multiple species of ticks. Compared to similar oral tablets, as well as other topical products, I find that Simparica works even more quickly than competitor products, starting to kill fleas within 3 hours, and ticks within 8 hours. Unlike other products labeled for monthly use, studies and my clinical experience show that Simparica is actually effective up to 35 days, not dropping off in efficacy as many other products do in killing fleas and ticks toward the end of the month. I also find that the many flexible dosing packages offer convenience to canine guardians, even in small dogs who weigh under 5 pounds. In addition to the efficacy against fleas and ticks, the product is also labeled effective against scabies mites. Many veterinarians and dermatologists are also now reaching for Simparica as a quick, safe and effective off-label treatment of demodex mange mites, which have long been very difficult to manage in veterinary medicine. I have found that in many cases one dose of Simparica will clear up many demodex mange cases within one month of the first pill. I have found that most dogs tolerate this product very well, especially when given with food. I have occasionally seen mild digestive upset in some sensitive pets, as well as rare neurological reactions. If a dog has a history of seizures, I would probably be cautious in using this product or ones of a similar class. Most dogs readily take this chewable tablet. I give this product an overall rating of a 4.5, with an efficacy of 4.5, and ease of use a 4.5. |